Hosehold Toxins and the solution

Hazardous Waste Disposal Chart

Real Dirt on Clean: Household Toxins Dossier

Information at above links includes:

Exposure to Household Chemicals
Vulnerability to Children
Asthma Population Statistics
Household Cleaners & Asthma
Toxicity of Household Cleaners
Environmental Impact of Chemicals in Household Products
Phosphate damage to aquatic life
Hazardous Waste Statistics
EPA tips on providing household hazardous waste
Poisoning Statistics
References

Doctors Are the Third Leading Cause of Death in the U.S.

Doctors Are the Third Leading

Cause of Death in the U.S.

Do you actively strive to achieve and maintain health?

Or do you wait for something to go wrong and then go to the doctor?

Do you know that being under a doctor’s “care” is the third leading cause of death?

That’s right! Solid fact! Right behind heart disease and cancer is death at the hands of the medical establishment.

Dr. Barbara Starfield of the Johns Hopkins School of Hygiene and Public Health, 250,000 deaths per year are caused by medical errors, making this the third-largest cause of death in the U.S., following heart disease and cancer.

Writing in the Journal of the American Medical Association (JAMA), Dr. Starfield has documented the tragedy of the traditional medical paradigm in the following statistics:

Deaths Per Year - Cause

106,000 Negative effects of drugs

80,000 Infections in hospitals

45,000 Other errors in hospitals

12,000 Unnecessary surgery

7,000 Medication errors in hospitals

Total deaths per year from iatrogenic* causes
250,000

· The term iatrogenic is defined as : induced by a physician or surgeon, or by medical treatment or diagnostic procedures

There are other studies that estimate the death toll from iatrogenic causes to be as high 700,000 but one quarter of a million is enough to get most people's attention.

So, do you want to prevent the need for a doctor by pro-actively striving for good health?

Or do you want to turn yourself over to the people who are the third leading cause of death in America because you haven’t done what you can to stay healthy?

Good, you have decided to stay healthy to avoid doctors!

The proven, scientifically validated, plan to stay healthy is very simple.
· Exercise daily! As little as 30 minutes a day will significantly protect your good health
· Eat sensibly and be aware that good choices (salad rather than ice cream) will pay good health dividends
· Use high quality nutritional supplementation (see study below)

Finally a “landmark” (20 year) nutritional study has been done that compares the dietary supplement usage patterns, health, and nutritional status of:

· Long-term multiple dietary supplement users, (persons who consume several high quality, organically sourced, cold processed nutritional supplements)
· to persons who use multivitamin/mineral vitamins (products sold at the grocery store, drug store and usually taken as one capsule a day)
· to non-users of nutritional supplements

Probably the most striking result of the study is that person who used no nutritional supplementation at all were actually healthier than the person who used the one capsule a day products.

The persons who used several high quality nutritional supplements (Shaklee products) over a long period of time were much less at risk for disease than non supplement users and the “one capsule a day” users.

BROCHURE
Download the study brochure (English).

CITATION View the study citation in PubMed,
a service of the U.S. National Library of Medicine and the National Institutes of Health.

Please contact us for free nutritional counseling and browse our Shaklee website at: www.shaklee.net/bestself

Watch this video clip - resveratrol product - it's in VIVIX

JANUARY 25, 2009:

As we heard this evening on 60 Minutes, the Resveratrol Product which will be available pharmaceutically in a pill form in about five years has now been shown to interrupt and delay the aging process, plus indications are that it might be used in treating diseases which include cancer, diabetes, Alzheimer’s, Parkinson’s etc. Yes, the research proved it would delay the effects of aging, but the fact that in the future, it would be used in the treatment of disease was an unexpected development.

Meanwhile, we do not have to wait for a pharmaceutical product, nor rely on a pill, when we already have all natural Vivix anti-aging extract. We can enjoy all the benefits with just one delicious teaspoon a day.

(note the comments on Vivix by Dr. Joseph Maroon below)

Without making any claims, we can confidently and enthusiastically present to the public the world's best anti aging tonic:

Vivix, which research has proven to address all four mechanisms of aging. Our Vivix is Resveratrol Plus the unique blend of polyphenols that make Vivix 10 times more powerful than resveratrol alone. Resveratrol is miraculous and we have gone beyond Resveratrol. The purity and percentage of resveratrol in a product is also an important consideration. With The Shaklee Corporation's heritage of integrity and the most extensive clinical research, we are once again number one with the best, and it's Vivix out in front all the way.


The book: “The Longevity Factor”, How Resveratrol & Red Wine activate genes for a longer and healthier life by Joseph Maroon, M.D.
Video clip of Dr. Maroon: http://www.youtube.com/watch?v=jJxfZInO7xI


On Page 193 Dr Maroon writes this on Vivix:

“There is growing evidence that a combination of resveratrol and other potent polyphenols might provide improved health benefits due to the synergistic properties of different polyphenols from different plant sources. Shaklee Corporation, a direct selling nutrition company has recently released a product called Vivix, which is described as a cellular anti-aging tonic. It contains a multi-source polyphenol blend. In conversations with the company, they state that the blend includes 100 mg of 98 percent pure resveratrol from Polygonum cuspidatum long with a proprietary extract derived from the fresh pomace of muscadine grapes (Vitis rotundifolia) The company recommends 5ml per day of Vivix, which they state is equivalent to the amount of resveratrol found in 100 glasses of red pinot noir red wine. The muscadine polyphenols in this blended product along with the added resveratrol, European elderberry extract, and purple carrot extract will increase the total overall polyphenol content of this product. A month's supply will cost a member $85.00. In Shaklee's accompanying literature for Vivix, they state that the Vivix ingredients were shown in a laboratory study to be 10 times more powerful in slowing a key mechanism of aging than resveratrol alone."

Also, on Page 70, the author expands on the value of the muscadine grapes and the advantages over European grapes.

"Muscadine grapes are native to North America, and may be the only fruit that originated in the United States and nowhere else. They grow almost exclusively in the southeastern United Sates. They thrive under adverse conditions, perhaps due to their thicker and tougher skins compared to European grapes....muscadines have an extra chromosome (twenty instead of the nineteen other grapes have). These additional genes allow muscadine grapes to produce a unique phytochemical, ellagic acid. The ellagive acid polyphenol compounds that are in muscadine grapes are virtually absent in other grapes. Ellagic acid is used by the muscadine grape skin to make tannin called ellagotannins, whichis used as an antimicrobial by the plant. Ellagic acid also has powerful antioxidant and anticancer properties....the polyphenols in muscadine grape skins have been shown to have positive effects in heart disease, high cholesterol, diabetes, metabolic syndrome, and other inflammatory conditions. One of the more interesting effects of muscadine products appears to be their inhibition of AGE protein formation."

Continuing, the author states:

" Recently, a large nutrition, direct selling company, Shaklee Corporation, working with scientists from the University of Georgia, has created a product containing an extract made from muscadine pomace which is the remaining fruit solids after the water content is extracted. Specifically, they are working with muscadine grape growers in order to secure grapes with large amounts of protective polyphenols including ellagic acid and resveratrol. By selecting muscadine grapes and by using a whole grape extraction process, they have reported that their extract has a significantly higher concentration of healthy polyphenols than found in the skins themselves."

The above are excerpts from the book "The Longevity Factor" The author Joseph Maroon, M.D. FA.C.S. studied medicine at Indiana University, and Oxford University. Dr Maroon is a world renowned neurosurgeon and former president of the Congress of Neurological surgeons, the largest society of its kind in North America. He is currently a professor and Heindl Scholor in Neuroscience at the University of Pittsburgh Medical Center. Interesting to note: he is a lifelong athlete, competed in more than fifty triathlons, and three Hawaiian Ironman Championship competitions.

The book is heralded as a groundbreaking examination of new scientific research that holds the secret to weight loss, increased strength, endurance, memory, and a healthier, longer life.

I believe the author, Joseph Maroon, M.D. has no connection with Shaklee Corporation, and the references in the book to Shaklee Corporation and our product Vivix..serve as an excellent third party reference.

Small Molecule Increases Lifespan and "Healthspan"

Small Molecule Increases Lifespan and "Healthspan" of Obese Mice

Risk of Death Cut By 31 Percent for Obese Mice Treated with Compound, and Treated Mice Seen Living as Long as Lean Mice

In Obese Mice, Molecule Reversed Nearly All Pathways Activated In Mice By High Calorie Diets

Findings Suggest Broad Implications for the Treatment of Age-related Diseases, Including Diabetes and Heart Disease

BOSTON-November 1, 2006-Researchers have used a single compound to increase the lifespan of obese mice, and found that the drug reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets--some of which are associated with diabetes, heart disease, and other significant diseases related to obesity. The research, led by investigators at Harvard Medical School and the National Institute on Aging, is the first time that the small molecule resveratrol has been shown to offer survival benefits in a mammal. The study is reported in the November 1 advanced online edition of Nature.

"Mice are much closer evolutionarily to humans than any previous model organism treated by this molecule, which offers hope that similar impacts might be seen in humans without negative side-effects," says co-senior author David Sinclair, HMS associate professor of pathology, and co-director of the Paul F. Glenn Labs for the Biological Mechanisms of Aging.

"After six months, resveratrol essentially prevented most of the negative effects of the high calorie diet in mice," said Rafael de Cabo, Ph.D., the study's other co-senior investigator from the National Institute on Aging's Laboratory of Experimental Gerontology, Aging, Metabolism, and Nutrition Unit. "There is a lot of work ahead that will help us better understand resveratrol's roles and the best applications for it."

Resveratrol is found in red wines and produced by a variety of plants when put under stress. It was first discovered to have an anti-aging properties by Sinclair, other HMS researchers, and their colleagues in 2003 and reported in Nature. The 2003 study showed that yeast treated with resveratrol lived 60 percent longer. Since 2003, resveratrol has been shown to extend the lifespan of worms and flies by nearly 30 percent, and fish by almost 60 percent. It has also been shown to protect against Huntington's disease in two different animal models (worms and mice).

"The "healthspan" benefits we saw in the obese mice treated with resveratrol, such as increased insulin sensitivity, decreased glucose levels, healthier heart and liver tissues, are positive clinical indicators and may mean we can stave off in humans age-related diseases such as type 2 diabetes, heart disease, and cancer, but only time and more research will tell," says Sinclair, who is also a co-founder of Sirtris, a company with an author on this paper and which is currently in a phase 1b trial in humans with diabetes using an enhanced, proprietary formulation of resveratrol. [Harvard has license and equity interests with Sirtris, which is not a public company.]

Investigators identified resveratrol while looking for compounds that activate Sir2, an enzyme linked to lifespan extension in yeast and other lower organisms. For the last 70 years, scientists have been able to increase the lifespan of a variety of species by reducing their normal food consumption by 30 to 40 percent - a diet known as calorie restriction. Through this research, scientists identified Sir2 as a key contributor to life extension. Without Sir2, for example, fruit flies see none of the benefits from either calorie restriction or treatment by resveratrol. The mammalian version of the Sir2 gene is SIRT1, which has the same enzymatic activity as Sir2, but modifies a wider variety of molecules throughout cells. Indicators in this study show that resveratrol might also be activating SIRT1 in mice, as well as other known longevity pathways.

How the Study Was Done
Survival Benefit
Reversing Genetic Pathways Triggered by High Calorie Diet
Improved Health Biomarkers: Glucose and Insulin
Organ Protection: Heart and Liver
Links to Calorie Restriction Lifespan Model
Links to SIRT1

How the Study Was Done
This study examined three groups of mice, one on a standard diet (SD), another on a high calorie diet (HC) with 60 percent of calories coming from fat, and a third group of mice on the same high calorie diet but also treated with resveratrol (HCR). At middle age, or roughly 52 weeks of life, the researchers put the mice on the different diets.



Survival Benefit
At 60 weeks of age, the survival rates of HC and HCR fed mice groups began to diverge and remained separated by a three to four month span. At 114 weeks of age, 58 percent of the HC fed mice had died, compared to 42 percent of the HCR and SD groups. Presently, the team has found resveratrol to reduce the risk of death from the HC diet by 31 percent, to a point where it is not significantly increased over the SD group.(Note: Given that mice are still living, final calculations can't be made.) "The median lifespan increase we are seeing is about 15 percent at this point," says Sinclair. "We won't have final lifespan numbers until all of the mice pass away, and this particular strain of mouse generally lives for two-and-a-half-years. So we are around five months from having final numbers, but there is no question that we are seeing increased longevity.

The team also found that the HCR fed mice had a much higher quality of life, outperforming the HC fed mice on motor skill tests. "The mice on resveratrol have not been just living longer," says Sinclair. "They are also living more active, better lives. Their motor skills actually show improvement as they grow older."
The resveratrol fed mice also showed improved motor function with age over its HC fed counterparts. Researchers watched how well the mice did walking on a rotarod, similar to walking on a log in the water, a common measure of balance and motor coordination. At 24 months of age, the HC fed group would fall off the rotarod after 60 seconds, while the HCR group would stay on for nearly 120 seconds. The HCR group steadily improved their motor skills as they aged to the point where they were indistinguishable from the SD fed group.

Reversing Genetic Pathways Triggered by High Calorie Diet
The research team also wanted to see if resveratrol could reverse the changes in gene expression patterns triggered by high calorie diets. Using liver tissue of five mice at 18 months of age from each group, the team performed a whole-genome microarray and identified which genes were turned on or off. The researchers then used a database generated by the Broad Institute that groups individual genes into common functional pathways to see where there were major differences.

"We made a striking observation," says Sinclair. "Resveratrol opposed the effects of high caloric intake in 144 out of 153 significantly altered pathways. In terms of gene expression and pathway comparison, the resveratrol fed group was more similar to the standard diet fed group than the high calorie group."

Improved Health Biomarkers: Glucose and Insulin
In humans, high calorie diets can increase glucose and insulin levels leading to diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. In the HC fed mice, researchers found biomarkers that might predict diabetes, including increased levels of insulin, glucose and insulin-like growth factor-1 (IGF-1). Conversely, the HCR fed group had significantly lower levels of these markers, paralleling the SD group. For example, a standard diabetes glucose test on the HCR fed group found considerably higher insulin sensitivity, meaning the HCR group had a lower disposition toward diabetes than the HC fed group. Lower insulin levels also predict increased lifespan in mice.

Organ Protection: Heart and Liver
Three pathologists examined heart tissue from the SD, HC, and HCR mice, and while not knowing which organ belonged to which mouse group, they looked for subtle changes in the abundance of fatty lesions, degeneration and inflammation. On a relative scale of 0-4, the assessment produced mean scores of 1.6 for the SD group, 3.2 for the HC group, and 1.2 for the HCR group.

The researchers also found that the livers of mice at 18 months of age on the HC diet were greatly increased in size and weight. Liver tissue studies of these mice showed a loss of cellular integrity, and a build-up of lipids, which is common to high fat diets. In contrast, the HCR group had normal, healthy livers.

Livers of mice at 18 months old: (left) normal diet; (center) high calorie diet; (right) high calorie diet + resveratrol.

Links to Calorie Restriction Lifespan Model
The researchers also looked for metabolic ties to resveratrol's impact: pathway changes that mimicked those caused by calorie restriction. They examined AMP-activated kinase (AMPK), a metabolic regulator that promotes insulin sensitivity and fatty acid oxidation. It's been shown in previous work that the lifespan of worms has been extended by the addition of copies the AMPK gene, and chronic activation of AMPK is seen on calorie-restricted diets. The researchers examined the livers of the HCR fed group and found a strong tendency for AMPK activation, as well as two downstream indicators of its activity.

Calorie restriction and exercise have also been previously shown to increase the number of mitochondria in the liver. Mitochondria generate energy in cells. Through electron microscopy, investigators showed that the livers of the HCR fed mice had considerably more mitochondria than the HC group, and were not significantly different from those of the SD group.

Links to SIRT1
The team also asked if SIRT1 was activated by resveratrol in mice, as Sir2 is in lower organisms. To determine this, they looked at the amount of a specific chemical modification (acetylation) on the molecule PGC-1alpha. Removal of the "acetyl" chemical groups on PGC-1alpha activates this protein so that it can turn on certain genes that generate mitochondria and turn muscle into the type suited for endurance. The only enzyme known to remove the acetyl chemical groups on PGC-1alpha is SIRT1, and therefore the activity of PGC-1alpha is one of the most reliable and specific markers of SIRT1 activity in mammals. The research team found that levels of PGC-1alpha were three-fold lower in the HCR fed mice than in the HC mice, consistent with what would be expected when SIRT1 was being activated by resveratrol.

"This work demonstrates that there may be tremendous medical benefits to unlocking the secrets behind the genes that control our longevity," says Sinclair, "No doubt many more remain to be discovered in coming years."

This study was supported by Paul F. Glenn and the Glenn Foundation for Medical Research, the U.S. National Institutes of Health and the National Institute on Aging, the Ellison Medical Research Foundation, the American Heart Foundation, and the American Diabetes Association.

For more information on diabetes, visit the Harvard Medical School Consumer Information page Diabetes. For updates on this topic, click to subscribe.

Contact:
John Lacey, Harvard Medical School, 617-432-0442 (public_affairs@hms.harvard.edu)
* * * * * * * * * * * * * * * * *
VIVIX: The science behind this breakthrough product
Vivix™ Cellular Anti-Aging Tonic:

This is the Best Self USA Shaklee web site where you can contact us or order all Shaklee products.http://www.shaklee.net/bestself

FDA Stuns Scientists, Declares Mercury in Fish to be Safe

FDA Stuns Scientists, Declares Mercury in Fish to be Safe for Infants, Children, Expectant Mothers!

by Mike Adams, the Health Ranger, December 17, 2008

In a truly astonishing betrayal of public safety (even for the FDA), the U.S. Food and Drug Administration today revoked its warning about mercury in fish, saying that eating mercury-contaminated fish no longer poses any health threat to children, pregnant women, nursing mothers and infants.

Last week, the FDA declared trace levels of melamine to be safe in infant formula. A few weeks earlier, it said the plastics chemical Bisphenol-A was safe for infants to drink. Now it says children can eat mercury, too. Is there any toxic substance in the food that the FDA thinks might be dangerous? (Aspartame, MSG, sodium nitrite and now mercury...)

This FDA decision on mercury in fish has alarmed EPA scientists who called it "scientifically flawed and inadequate," reports the Washington Post. Even better, the Environmental Working Group (www.EWG.org) issued a letter to the EPA, saying "It's a commentary on how low FDA has sunk as an agency. It was once a fierce protector of America's health, and now it's nothing more than a patsy for polluters."

Is anyone really surprised? The FDA is a drug-pushing, people-betraying, scientifically illiterate criminal organization that, time and time again, seeks only to protect the profits of powerful corporations whose products poison the people. This statement is no longer a mere opinion. It is an observable fact based on the FDA's own pattern of behavior and its outlandish decisions that predictably betray the American public.


The real reason this is happening
You want to know the REAL reason the FDA is easing up on its warning about mercury in fish? It's because the agency is being relentlessly pounded over two related issues: Mercury in dental fillings and mercury preservatives in vaccines. And the FDA can't keep up its lie about the "safety" of vaccines and mercury fillings if it has already declared mercury to be dangerous in fish, right?

To the criminal minds running the FDA, the clever solution is to revoke the warning about mercury in fish. Thus, the FDA takes the position that all mercury is safe, and suddenly they're off the hook on mercury fillings and thimerosal in vaccines.

In other words, the FDA has just aligned itself as a defender of one of the most neurotoxic substances that's ever been found. Only a truly corrupt regulator could even attempt to defend such a position, and only a truly insane individual could argue that mercury exposure is safe for infants, children and expectant mothers. Not coincidentally, mercury exposure causes insanity (look up the historical term "mad as a hatter").

Given that most of the FDA decision makers probably have mercury fillings in their mouths and mercury molecules lodged in their brains from getting their vaccine shots, it's no stretch to consider the possibility that the FDA decision have, in a very strict medical sense, lost their minds due to mercury exposure. There's hardly any other way to explain the mad behavior of FDA officials.

I think it's time we called for an FDA MUTINY and declared the leaders of that agency to be too incompetent to run it anymore. These people need to be relieved of command before their hazardous pronouncements lead to yet more consumers being poisoned or killed. The FDA scientists, in my opinion, should revolt (in a non-violent way, of course) against the politically-motivated decision makers spewing all this "eat more poison" advice.

http://www.naturalnews.com/News_000622_mercury_FDA_fish.html

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Ultra-pure, full-spectrum potency of seven omega-3s

Product Info Sheet

VIVIX: The science behind this breakthrough product

Vivix™ Cellular Anti-Aging Tonic:

The science behind this breakthrough product: read below or click here

Unlocking the secrets of biological aging is perhaps the ultimate scientific quest—and significant progress has occurred in the last decade in the understanding of the aging process. Scientists and the general public have become aware of the compelling research on a compound found in red wine called resveratrol, and its ability to extend lifespan in many different laboratory studies. Indeed, resveratrol has been referenced in over 2,000 research citations by the National Library of Medicine, including studies conducted by Harvard University, the National Cancer Institute, and the National Institute on Aging.

Launched in August 2008 ,* Vivix™ cellular anti-aging dietary supplement has captured the attention of people across America in just a few short months. Vivix was specifically designed to address 4 key mechanisms of cellular aging and Shaklee has the scientific substantiation to back up all claims for the ingredients in Vivix:

•Help protect and repair cellular DNA
•Positively impact genetic regulators
•Promote mitochondrial biogenesis
•Slow AGE protein formation

The genesis of Vivix coincided with a landmark research study published in the journal Nature in 2006.

This laboratory study surfaced the potential of resveratrol, a compound in red wine, to address two key mechanisms of cellular aging including improving mitochondrial biogenesis and activating genetic regulators of longevity pathways. Numerous laboratory studies including those cited below confirm an effect of resveratrol on helping to protect against a third mechanism of cellular aging, the protectionand repair of DNA damage.

But Shaklee scientists went beyond resveratrol in the creation of Vivix by creating a unique and patentpending polyphenol blend that adds to the power of resveratrol. While resveratrol addresses 3 of 4 of the key mechanisms of aging, it is not very effective in addressing the formation of AGE proteins which can compromise cellular integrity and longevity. So Shaklee scientists identified and created a proprietary Rejuvetrol™ polyphenol blend that has been shown to be 10X more powerful thanresveratrol alone at addressing this 4th mechanism of cellular aging.

So, to help review the science supporting Vivix claims, we’ve included the citations of key studies that have been used to validate and support the most important claims we make, including:

“In laboratory studies, Vivix™ ingredients have been shown to impact four key mechanisms of cellular aging.*”

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Helps protect and repair cellular DNA

1. Usha, S., Irudayam, M.J., Malathi, R., “Interaction of Resveratrol and Genistein with Nucleic Acids”, Journal of Biochemistry and Molecular Biology, Vol 38, No. 2, March 2005, pp. 198-205

2. Niture, S., Velu, C., Smith, Q, Bhat, J., Srivenugopal, K, “Increased Expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventive natural products in human lymphocytes and tumor lines,” Carcinogenesis, Vol 28, no. 2, pp 378-389, 2007

3. Yang, S., Irani, K., Heffron, S., Jurnack, F., Meyskens, F., “Alterations in the expressions of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor” Molecular Cancer Therapeutics, 4(12), December 2005

4. Zahid, M., Gaikwad, N.W., Rogan, E.G., Cavalieri, E.L., “Inhibition of depurinating estrogen-DNA adduct formation by natural compounds,” Chemical Research in Toxicology, 20 (12): 1947-53, December 2007

5. Chakraborty S, Roy, M, Bhattacharya RK, “Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis,” Environmental Pathology, Toxicology, and Oncology, 2004; 23(3): 215-26

6. Gatz SA, Keimling M, Baumann C, Dörk T, Debatin KM, Fulda S, Wiesmüller L, “Resveratrol modulates DNA doublestrand break repair pathways in an ATM/ATR-p53- and –Nbs1-dependent manner” Carcinogenesis, 2008 Mar; 29 (3):51927. Epub 2008 Jan 3.

Positively impacts genetic regulators

1. Pearson, K., Baur, J., Lewis, K., Peshkin, L. et al., “Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span,” Cell Metabolism, 2008

2. Barger J.L., Kayo, T., Pugh, T.D., Prolla, T.A., Weindruch, R., “Short term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart,” Experimental Gerontology (2008), doi: 10.1016/j.exger.2008.06.013

3. Barger, J., Kayo, T., Vann, J., Arias, E., Wang, J., Hacker, T., Raederstorff, D., Morrow, J., Leeuwenburgh, C., Allison, D.,Saupe, K., Cartee, G., Weindruch, R., Prolla, T., “A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice,” PLoS ONE, 3(6): e2264, doi:10.1371/journal.pone.0002264

4. Howitz, KT, Bitterman KJ, Cohen, HY, Lamming, DW, Lavu, S, Wood JH, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA, “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan,” Nature 2003 nov 11;425(6954): 191-6. Epub 2003 Aug 24

Promotes mitochondrial biogenesis

1. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., et al. “Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α,” Cell, Vol 127, 1109-1122, December 15, 2006

2. Dasgupta, B., Milbrandt, J., “Resveratrol stimulates AMP kinase activity in neurons,” Proceedings of the National Academy of Sciences, Vol 104, no. 17, April 24, 2007

3. St-Pierre, J. Drori, S., Uldry, M., Silvaggi, J., Rhee, J., Jäger, S., Handschin, C., et al., “Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators,” Cell, Volume 127, 397-408, October 20, 2006

4. Civitarese, A., Carling, S., Heilbronn, L., Hulver, M., Ukropcova, B., Deutsch, W., Smith, S., Ravussin, E., “Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans,” PLoS Medicine, Vol 4, Issue 3, March 2007

5. Lopez-Lluch, G., Irusta, P., Navas, P., de Cabo, R., “Mitochondrial biogenesis and healthy aging,” Experimental Gerontology, Vol 43, 813-819, 2008

Slows AGE protein formation

1. Farrar, J., Hartle, D., Hargrove, J., Greenspan, P., “Inhibition of protein glycation by skins and seeds of the muscadinegrape” BioFactors, Vol 30, 193-200, 2007

2. Hudson, T., Hartle, D., Hursting, S., Nunez, N., Wang, T. Young, H., Arany, P., Green, J., “Inhibition of Prostate Cancer Growth by Muscadine Grape Skin Extract and Resveratrol through Distinct Mechanisms,” Cancer Research 2007, 67: (17), September 1, 2007

3. Bralley, E., Greenspan, P., Hargrove, J., Hartle, D., “Inhibition of Hyarluronidase Activity by Vitis rotundifolia (Muscadine) Berry Seeds and Skins, “ Pharmaceutical Biology, Vol 45, No. 9, pp 667-673, 2007

4. Ramasamy, R., Vannucci, S., Shi Du Yan, S., Herold, K., Yan, S., Schmidt, A., “Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation,” Glycobiology, vol. 15 no. 7 pp. 16R–28R, 2005

Guidance on Resveratrol Dosage and Safety

1. Reagan-Shaw, S., Nihal, M., Ahmad, N., “Dose translation from animal to human studies revisited” The FASEB Journal, fj.07-9574LSF, published online October 17, 2007

2. Baur, J., Pearson, K., Price, N., Jamieson, H., Lerin, C., Kalra, A., et al. “Resveratrol improves health and survival of mice on a high calorie diet,” Nature, Volume 444, November 16, 2006

3. Juan, M., Vinardell, M., Planas, J., “The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days is Not Harmful,” The Journal of Nutrition, 132: 257-260, 2002

4. Crowell, J., Korytko, P., Morrissey, R., Booth, M., Levine, B., “Resveratrol-Associated Renal Toxicity,” Toxicological Sciences, 82, 614-619, 2004

5. Boocock, D., Faust, G., Patel, K., Schinas, A., Brown, V., Ducharme, M., et al., “Phase 1 Does Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent,” Cancer Epidemiology Biomarkers & Prevention 2007, 16(6), June 2007


ABC Barbara Walters – Dr. Sinclair and Resveratrol
http://www.youtube.com/watch?v=jCBKfqanYX0

A conversation with Dr. David Sinclair of The Harvard Medical School and Nicholas Wade, the science reporter for "The New York Times" about a groundbreaking new health study involving a molecule called resveratrol. The molecule, found in grapes and therefore wine, offsets the effects of high caloric intake in obese mice and also extends their longevity. (55 min) well worth the time!
http://www.charlierose.com/shows/2006/11/02/1/a-conversation-with-dr-david-sinclair-and-nicholas-wade

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This is the Best Self USA Shaklee web site where you can contact us or order all Shaklee products.http://www.shaklee.net/bestself

Supplements - wellness, sickness or no difference?

Supplements - wellness, sickness or no difference?

For more information on this Landmark Study:
BunnySam@bestselfusa.com

Friends and Partners,

Our Shaklee meetings will get down to the scientific truth about the effectiveness of nutritional supplementation.

Recently the University of California at Berkley did a long term (20 year) study of the effectiveness of supplements. The scientists who conducted this research are leaders in their field.

The study was published in a peer reviewed scientific journal:
Gladys Block, Christopher D Jensen, Edward P Norkus, Tapashi B Dalvi, Les G Wong, Jamie F McManus and Mark L Hudes.

Nutrition Journal 2007, 6:30doi:10.1186/1475-2891-6-30Published 24 October 2007http://www.landmarkstudy.com/

BROCHURE:
Download the study brochure (English).
Download the study brochure (Spanish).

MANUSCRIPTView the study manuscript published in Nutrition Journal.

CITATIONView the study citation in PubMed, a service of the U.S. National Library of Medicine and the National Institutes of Health.

Contact us thru our website: http://www.shaklee.net/bestself

We look forward to hearing from you .

bunnysam@bestselfusa.com
or 591-4565
10202 Vanderbilt Dr (NE corner at 102nd Ave)
Naples, Fl 34108